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Giornale Italiano di Dermatologia e Venereologia 2018 June;153(3):389-95

DOI: 10.23736/S0392-0488.17.05774-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The association between serum vitamin D levels and urticaria: a meta-analysis of observational studies

Xiaoyan WANG 1, Xiaorong LI 1, Yiwei SHEN 2, Xueyan WANG 1

1 Department of Allergology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; 2 Research Division, Beijing Shijitan Hospital, Capital Medical University, Beijing, China



INTRODUCTION: Despite the recent studies revealed Vitamin D may play a role in urticaria, no meta-analysis providing definite conclusions in this field has been reported.
EVIDENCE ACQUISITION: A systematic search up to June 30th, 2017 was conducted in MEDLINE (via PubMed) and Excerpta Medica database (EMBASE) to identify relevant articles. Search terms included ‘‘vitamin D’’ or “25-hydroxyvitamin D” or “25-hydroxy-vitamin D” or “25(OH)D” or “1,25-dihydroxyvitamin D” combined with ‘‘urticaria.”
EVIDENCE SYNTHESIS: Initial searches yielded 30 citations. Of these original results, 10 met specific selection criteria and were included in the meta-analysis with 547 urticaria cases and 517 controls. Vitamin D levels were significantly decreased in the urticarial cases (WMD -9.8 mg/L, 95% CI: -12.57 to -7.04 mg/L, from a random effects model), with a significant heterogeneity (I2=85.9%, P=0.000). When divide the Vitamin D level into two subgroups, the pooled OR comparing vitamin D insufficiency vs. normal level was 1.64 (95% CI: 0.71 to 3.77). Meanwhile, vitamin D deficiency vs. normal level was 4.09 (95% CI: 1.32 to 12.73).
CONCLUSIONS: The study demonstrated that patients with urticaria had a lower Vitamin D level than healthy controls. Vitamin D deficiency rather than insufficiency has a positive relationship with urticaria. However, larger-scale studies with a longer duration of treatment are needed to confirm this conclusion.


KEY WORDS: Vitamin D - 25-hydroxyvitamin D - Urticaria - Meta-analysis - Observational study

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