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REVIEW  RHEUMATOLOGIC DERMATO(PATHO)LOGY: HOW THE MICROSCOPE CAN HELP THE CLINICIAN 

Giornale Italiano di Dermatologia e Venereologia 2018 April;153(2):265-72

DOI: 10.23736/S0392-0488.18.05841-8

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Neutrophilic dermatoses: a broad spectrum of disease

Alessandra FILOSA 1, Giorgio FILOSA 2

1 Anatomic Pathology, Hospital of Macerata, AREA Vasta 3 ASUR Marche, Macerata, Italy; 2 Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy


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The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses.


KEY WORDS: Neutrophils - Autoimmune diseases - Sweet syndrome

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