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REVIEW  RHEUMATOLOGIC DERMATO(PATHO)LOGY: HOW THE MICROSCOPE CAN HELP THE CLINICIAN Freefree

Giornale Italiano di Dermatologia e Venereologia 2018 April;153(2):256-64

DOI: 10.23736/S0392-0488.18.05836-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Dermatomyositis: clinicopathological correlations

Paolo SENA 1 , Andrea GIANATTI 2, Daniele GAMBINI 1

1 Unit of Dermatology, Papa Giovanni XXIII Hospital, Bergamo, Italy; 2 Unit of Pathology, Papa Giovanni XXIII Hospital, Bergamo, Italy


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Dermatomyositis (DM) is a chronic autoimmune disease affecting primarily the skeletal muscle and the skin. Although the diagnosis is usually based upon clinical and laboratory findings, histopathology is helpful for confirmation purposes and is mandatory in amiopathic DM where there is only skin involvement. Histologically, the typical cases are characterized by subtle vacuolar interface alterations with epidermal atrophy, mild capillary ectasia and sparse perivascular lymphocytic infiltrate; these findings are similar to those seen in other connective tissue diseases, especially lupus erythematosus. This review deals with the specific histological findings that can be found in the different presentations of the disease and discuss the most common differential diagnoses. As for many other inflammatory skin diseases, the diagnosis of DM is based on a strict interaction between the dermatologist and the dermatopathologist.


KEY WORDS: Myositis - Dermatomyositis - Pathology

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