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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2018 April;153(2):161-4

DOI: 10.23736/S0392-0488.17.05742-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients

Maria V. CANNIZZARO , Annunziata DATTOLA, Virginia GAROFALO, Ester DEL DUCA, Luca BIANCHI

Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy


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BACKGROUND: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment. We conducted a randomized controlled trial to evaluate the efficacy of a cream compound formulated in order to reduce the oral isotretinoin side effects (redness, dryness, itching) in patients affected by severe acne of the face.
METHODS: Twenty-seven patients undergoing treatment with 0.5-1 mg/kg/day for papulo-pustular or nodulo-cystic acne were randomized to additionally receive a cream composed of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide applied twice daily (group A) or placebo cream (group B) applied 2 times per day.
RESULTS: During the whole treatment period and after 6 months of treatment, patients in the group A showed a greater reduction of dryness, itching and redness compared to the group receiving the placebo cream.
CONCLUSIONS: The cream formulated with 8% omega-ceramides, hydrophilic sugars, 5% niacinamide was effective in reducing xerosis and skin irritation, and was also successful in improving the patients’ adherence to the oral isotretinoin treatment.


KEY WORDS: Acne vulgaris - Isotretinoin - Treatment adherence and compliance

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Publication History

Issue published online: March 20, 2018
Manuscript accepted: December 4, 2017
Manuscript revised: November 22, 2017
Manuscript received: July 26, 2017

Cite this article as

Cannizzaro MV, Dattola A, Garofalo V, Del Duca E, Bianchi L. Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients. G Ital Dermatol Venereol 2018;153:161-4. DOI: 10.23736/S0392-0488.17.05742-X

Corresponding author e-mail

mariavittoria.cannizzaro@gmail.com