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Giornale Italiano di Dermatologia e Venereologia 2018 February;153(1):56-67

DOI: 10.23736/S0392-0488.17.05768-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Current standards of surgical management in primary melanoma

Matthew C. PEREZ, Sonia T. ORCUTT, Jonathan S. ZAGER

Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA


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Melanoma accounts for the majority of skin cancer-related deaths, and its incidence continues to rise worldwide. While advanced disease has historically been associated with poor long-term survival, early-stage disease has a favorable prognosis and therefore, early diagnosis is paramount. Resection of primary melanoma requires a balance of maximizing oncological outcome while minimizing morbidity. Wide excision with 1-2 cm margins, depending on depth of the tumor, is the standard of care for surgical treatment of primary, invasive melanoma. Sentinel lymph node biopsy is indicated for patients with clinically node-negative, intermediate-thickness primary melanomas but should also be considered in selected patients with thin and thick primaries. In this article, historical perspectives and key clinical trials regarding the current guidelines for the surgical management of primary melanoma are discussed.


KEY WORDS: Melanoma - Surgery - Sentinel lymph node biopsy

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