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Giornale Italiano di Dermatologia e Venereologia 2018 February;153(1):19-25

DOI: 10.23736/S0392-0488.16.05373-6

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Electrochemotherapy for basocellular and squamocellular head and neck cancer: preliminary experience in Day Surgery Unit

Mauro MONTUORI 1 , Letizia SANTURRO 1, Andrea FELIZIANI 2, Flavio DE SANCTIS 2, Edoardo RICCIARDI 2, Daniele GAUDIO 3, Elena CAMPIONE 4, Luca BIANCHI 4, Maria B. SILVI 3, Piero ROSSI 1

1 Department of Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy; 2 Department of Surgery, University Hospital of Tor Vergata, Rome, Italy; 3 Department of Anesthesiology and Intensive Care, University Hospital of Tor Vergata, Rome, Italy; 4 Department of Dermatologic Surgery, University Hospital of Tor Vergata, Rome, Italy


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BACKGROUND: The aim of this study was to evaluate feasibility, safety and efficacy in day surgery of electrochemotherapy (ECT) using bleomycin in non-melanoma head and neck skin cancer.
METHODS: We performed a prospective study on fifteen patients treated at the General Surgery Department at University Hospital of Tor Vergata, Rome between April 2011 and February 2013.
RESULTS: We observed 100% complete response evaluated with WHO criteria at 6 weeks after treatment. No partial response was achieved.
CONCLUSIONS: ECT is a simple, highly effective and safe treatment for head and neck non melanoma skin cancer. In our experience ECT can be performed safely in Day Surgery also in patients ASA III. Side effects associated with ECT are minimal and the treatment is well tolerated also by older patients, with minimal impairment of organ function and healthy tissues and with good esthetic results. We would encourage this treatment especially for older patients with multiple comorbidities, in which conventional surgical approach is not easily practicable.


KEY WORDS: Electrochemotherapy - Bleomycin - Head and neck neoplasms - Carcinoma, basal cell - Carcinoma, squamous cell

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