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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 December;152(6):638-41

DOI: 10.23736/S0392-0488.16.05442-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Prognostic role of histological regression in cutaneous melanoma

Simone RIBERO 1, 2 , Simona OSELLA-ABATE 3, Emi DIKA 4, Eugenio SPORTOLETTI BADUEL 2, Elena MARRA 1, Franco PICCIOTTO 2, Virginia CALIENDO 2, Maria T. FIERRO 1, Pietro QUAGLINO 1

1 Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; 2 Section of Dermatologic Surgery, Department of Oncology, University Hospital “Città della Salute e della Scienza di Torino”, Turin, Italy; 3 Section of Surgical Pathology, Department of Medical Sciences, University of Turin, Turin, Italy; 4 Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy


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Histological regression in primary cutaneous melanoma occurs in 10-35% of cases. Although there is a large body of literature on histological regression and prognosis in melanoma patients, not clear data concerning this feature has been reported. In the current review, a comprehensive overview of the main aspects of regression will be provided. The clinical utility of regression as a prognostic factor has been challenged recently. Nowadays evidences reported that this feature is protective on SLN metastases. Despite its association with poor prognostic factors, it maintained a favourable prognostic role in many different survival studies.


KEY WORDS: Melanoma - Survival - Histology

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Publication History

Issue published online: October 18, 2017
Article first published online: November 15, 2016
Manuscript accepted: November 2, 2016
Manuscript received: August 23, 2016

Cite this article as

Ribero S, Osella-Abate S, Dika E, Sportoletti Baduel E, Marra E, Picciotto F, et al. Prognostic role of histological regression in cutaneous melanoma. G Ital Dermatol Venereol 2017;152:638-41. DOI: 10.23736/S0392-0488.16.05442-0

Corresponding author e-mail

simone.ribero@unito.it