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Giornale Italiano di Dermatologia e Venereologia 2017 June;152(3):308-10

DOI: 10.23736/S0392-0488.17.04876-3

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus

Maryam S., SADATI 1, Ladan DASTGHEIB 1, Elham AFLAKI 2

1 Department of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 2 Department of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran


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Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease, without any well-known specific and effective treatment. Here we report two patients with severe recalcitrant perineal pyoderma gangrenosum, successfully treated with low dose systemic tacrolimus. Tacrolimus can be a safe effective drug in the management of recalcitrant PG.


KEY WORDS: Pyoderma gangrenosum - Perineum - Tacrolimus

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