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Giornale Italiano di Dermatologia e Venereologia 2017 April;152(2):109-16

DOI: 10.23736/S0392-0488.16.05270-6

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Psoriasis in melanoma patients: a prospective pilot study

Matteo MEGNA, Maddalena NAPOLITANO, Nicola BALATO, Massimiliano SCALVENZI, Fabio AYALA, Luisa DI COSTANZO, Serena LEMBO, Roberta DI CAPRIO, Cataldo PATRUNO, Anna BALATO

Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy


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BACKGROUND: Melanoma is an immunogenic tumor and the presence of T-cell infiltrates within melanoma lesions may correlated with longer patient survival. Psoriasis is a chronic immune-mediated inflammatory disease, in which the role of T-cells is well established. The aim of our prospective pilot study was to investigate the relationship between melanoma and psoriasis examining 3 groups of patients: the melanoma-group (MG), the psoriasis-group (PG) and the control-group (CG).
METHODS: Every patient underwent detailed anamnestic and clinical examination. Moreover, gene expression of interleukin-6 (IL-6), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) was analyzed in all groups and in subjects affected by both melanoma and psoriasis (MP).
RESULTS: Melanoma patients showed a lower frequency of psoriasis and positive family history (FH) of psoriasis respect to CG. Moreover, psoriatic patients presented fewer MN, and lower frequency of positive FH of melanoma than CG. IL-6 and IFN-γ were significantly increased in PG and reduced in MG.
CONCLUSIONS: We propose a provocative hypothesis of a possible protective role of psoriasis for melanoma development.


KEY WORDS: Psoriasis - Pigmented nevus - Melanoma - Tumor necrosis factor-alpha - Interleukin-6 - Interferon-gamma

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