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Giornale Italiano di Dermatologia e Venereologia 2015 February;150(1):123-9

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Degos disease: report of a case and review of the literature

Feci L. 1, Rubegni P. 1, Nami N. 1, Cerroni L. 2, Fimiani M. 1

1 Dermatology Section, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy; 2 Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria


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We report the case of a 20-year-old woman with one-year history of asymptomatic pink papules on the abdomen, with central atrophy. Fever and symptoms suggesting involvement of other organs were absent. Histological examination revealed wedge-shaped area of cutaneous ischemia extending into the deep dermis with superficial and deep perivascular lymphocytic infiltrate. On this basis, we diagnosed malignant atrophic papulosis. Laboratory tests and instrumental investigation did not reveal any systemic involvement. The rarity of this disease makes early diagnosis challenging, even if clinical and histological patterns of the skin lesions are peculiar.

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