Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2014 April;149(2) > Giornale Italiano di Dermatologia e Venereologia 2014 April;149(2):243-62

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

  DRUG ERUPTIONS - Part I 

Giornale Italiano di Dermatologia e Venereologia 2014 April;149(2):243-62

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

From erythema multiforme to toxic epidermal necrolysis. Same spectrum or different diseases?

Tomasini C. 1, Derlino F. 2, Quaglino P. 3, Caproni M. 4, Borroni G. 2

1 Dermatopathology Section, Department of Medical Sciences, University of Turin, Turin, Italy; 2 Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Dermatology Section, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 3 Dermatologic Clinic, Department of Medical Sciences University of Turin, Turin, Italy; 4 Section of Dermatology, Department of Critical Care University of Florence, Florence, Italy


PDF


Erythema multiforme (EM), Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute bullous disorders associated to different prognosis, mainly due to infections and drugs. More in particular EM in more than 90% is caused by infections (especially Herpes virus infection), while, on the other hand SJS and TEN are referable in more than 95% of cases to drugs. Distinction among these three forms is often controversal and still debated. An attempt to distinguish these forms has been possible mainly according to anamnesis, clinical presentation (morphology, involved sites, extension of lesions) and pathogenetic mechanisms, being on the contrary more difficult from an histopathological point of view. Nowadays a clear diagnosis and a distinction from other life-threatening diseases is possible with the integration of all the mentioned aspects. Moreover, this recognition should be as early as possible in order to perform a prognostic evaluation of the case and to start supportive cares and therapies as soon as possible.

top of page