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Giornale Italiano di Dermatologia e Venereologia 2013 December;148(6):673-8

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Lichen sclerosus and the risk of malignant progression: a case series of 159 patients

Paolino G., Panetta C., Cota C., Muscardin L., Donati P., Di Carlo A.

Dermatopathological Unit San Gallicano Institute – IRCCS, Rome, Italy


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Aim and methods: We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous-hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed.
Results and conclusion: The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).

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