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  PANNICULITIDES: THE SPECTRUM OF THEIR DIAGNOSES AND DIFFERENTIAL DIAGNOSES 

Giornale Italiano di Dermatologia e Venereologia 2013 August;148(4):387-94

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Panniculitis with vasculitis

Ferrara G. 1, Stefanato C. M. 2, Gianotti R. 3, Kubba A. 4, Annessi G. 5

1 Anatomic Pathology Unit Gaetano Rummo General Hospital, Benevento, Italy; 2 Department of Dermatopathology St John’s Institute of Dermatology, St Thomas’ Hospital, London, UK; 3 Department of Pathophysiology and Transplantation University of Milan, Milan, Italy; 4 Delhi Dermpath Laboratory, New Delhi, India; 5 Dermatopathology Unit, Istituto Dermopatico dell’Immacolata IRCCS, Rome, Italy


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Panniculitides encompass a great number of different entities; however, once a vasculitis has been detected histopathologically within the subcutaneous tissue, the differential diagnosis is mainly restricted to polyarteritis (panarteritis) nodosa (PAN), nodular vasculitis (NV), and Bazin’s erythema induratum (EI). Patients with PAN may have the disease confined to the skin, but must be followed over a long period because many of them develop late systemic disease. The NV/EI group represents by far the most common type of lobular panniculitis with vasculitis; we prefer keeping the distinction between the two entities by underlining the equation NV positive tuberculin skin test = EI. Other lobular panniculitides with vasculitis are exceedingly rare and set in a systemic background which can be infectious (lepromatous leprosy panniculitides) or autoimmune/dysreactive (neutrophilic lobular panniculitis in rheumaotoid arthritis, lobular panniculitis in inflammatory bowel disease).

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