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Giornale Italiano di Dermatologia e Venereologia 2012 February;147(1):119-21

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: English

Papular-purpuric “gloves and socks” syndrome

Bilenchi R., De Paola M., Poggiali S., Acciai S., Feci L., Sansica P., Fimiani M.

Section of Dermatology, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy


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Papular-purpuric “gloves and socks” syndrome (PPGSS), is an acute dermatosis characterized by a papular-purpuric edematous rash in a distinct ‘‘gloves and socks’’ distribution often accompanied by fever, asthenia and lymphadenophaties. It is mainly caused by parvovirus B19 (B19V) but other viruses and drugs such as trimethoprim/sulfametaxol or chemotherapics may be involved. We describe a case of PPGSS with a serologically proven B19V infection in a 42-year-old Italian kindergarten teacher suffering from acute bacterial pharyngitis Immunoglobulin M by enzyme-linked immunosorbent assay (ELISA) to parvovirus B19 were positive. Histological examination showed dermal-ipodermal inflammation with evidence of leukocytoclastic vasculitis principally interesting the small venules The cutaneous rash resolved after 2 weeks. We reported our case to support that PPGSS is an immunomediated disease and that B19V morbidity varies with the immunologic and hematologic status of the host. In addition, a patient with PPGSS might be infectious at the moment of diagnosis, with significant implication for susceptible contacts.

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