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Giornale Italiano di Dermatologia e Venereologia 2012 February;147(1):65-9

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: English

New insights about delayed allergic hypersensitivity to corticosteroids

Baeck M. 1, Goossens A. 2

1 Departement of Dermatology,, Saint-Luc University Clinic, Louvain Catholic University, Bruxelles, Belgium; 2 Departement of Dermatology, University Hospital, Leuven Catholic University Hospital, Leuven, Belgium


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Corticosteroids are among the most commonly used drugs, both topically and systemically. Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. With regard to cross-reactions between corticosteroids, based on patch-test results and molecular modelling, we were recently able to simplify the previous classification into 3 different groups, i.e., Group 1: the non-methylated, most often non-halogenated molecules (Group A, D2 and budesonide), which produce most of the allergic reactions; Group 2: the halogenated molecules with a C16/C17 cis ketal/diol structure (acetonide Group B); and Group 3: the halogenated and C16-methylated molecules (Group C and D1) that only rarely produce allergy.

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