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Giornale Italiano di Dermatologia e Venereologia 2011 February;146(1):53-6


language: English

Contact hypersensitivity to epoxy resin, methyldibromoglutaronitrile, tixocortol pivalate and budesonide in Hungary: a study in 1448 patients

Pónyai G., Németh I., Husz S., Jurcsik Á., Nebenführer L., Dinnyés M., Némethy P., Kohánka V., Temesvári E.

Department of Dermatology, Venerology and Dermato-oncology of Semmelweis University, Budapest, Hungary Department of Dermatology and Allergology of the Szent-Györgyi Albert Clinical Centre Szeged, Hungary Department of Dermatology of Flór Ferenc Hospital, Kistarcsa, Hungary Dermatological Outpatient, Department of the Unified Szt. István- Szt. László Hospital, Budapest, Hungary Dermatological Outpatient Department Szentendre, National Work Hygieneand Occupational Healthcare Institute, Budapest, Hungary


AIM: In order to map the frequency of contact hypersensitivity (CH) to epoxy resin, methyldibromoglutaronitrile (MDBGN), tixocortol pivalate (TP) and budesonide patch tests were carried out.
METHODS: The tests were performed in 1 448 patients. Most patients belong to the allergic and irritative contact dermatitis groups. The tests were administered with the allergens epoxy resin 1%, MDBGN 0.3%, TP 1% and budesonide 0.1%, applied on the back. Reactions were evaluated at 40 min, on day 2 (D2), day 3 (D3) and day 4 (D4). In the patients of the Dept. of Dermatology, Venerology and Dermatooncology of Semmelweis University (patients number =1 073) reactions were evaluated on day 7 as well.
RESULTS: Epoxy resin elicited immediate reactions in 1 patient at 40 min. Further evaluations showed no difference on D3, D4 and D7 with a frequency of CH of 1.03%. Patch testing for MDBGN did not provoke immediate reactions, evaluations showed an increasing hypersensitivity rate (D2: 0.93%; D7:1.77%). Patch tests with TP yielded no immediate reactions, the frequency of CH increased from 0.47% (D2) to 2.01% (D7). No immediate reactions were observed by budesonide; an increase was seen in frequency of CH (D2:0.93% to D7:3.84%). CH to the studied allergens was observed mostly in allergic contact dermatitis group, to budesonide in irritative contact dermatitis and in atopic dermatitis groups as well.
CONCLUSION: The data of the present study are the first results about this four allergens in Hungary and to our knowledge from our region as well.

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