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Giornale Italiano di Dermatologia e Venereologia 2009 February;144(1):93-6

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Erlotinib-induced pustular eruption

Cusano F. 1, Ferrara G. 2, Barletta E. 3, Ingordo V. 4

1 Unit of Dermatology, “G. Rummo” Hospital Benevento, Italy 2 Unit of Pathologic Anatomy, “G. Rummo” Hospital Benevento, Italy 3 Unit of Oncology, “G. Rummo” Hospital Benevento, Italy 4 Department of Dermatology, “G. Venticinque” Italian Navy Main Hospital, Taranto, Italy


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The epidermal growth factor receptor (EGFR) inhibitor erlotinib was found to significantly improve overall survival, time to progression, and cancer-related symptoms in locally advanced or metastatic non small cell lung carcinoma (NSCLC). Unfortunately, cutaneous side effects are not rare, the most common one being a follicular acneiform eruption. As it has been observed a positive correlation between rash severity and objective tumor response, it is critical for dermatologists early distinguish it from rashes carrying a different prognosis and needing a different management.

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