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Giornale Italiano di Dermatologia e Venereologia 2008 December;143(6):395-408

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

The treatment of mycosis fungoides

Sebastian Mestel D. 1, Beyer M. 1, Steinhoff M. 1, Sterry W. 1, Assaf C. 1, 2

1 Department of Dermatology and Allergy Skin Cancer Center Charité-Universitaetsmedizin, Berlin, Germany 2 Department of Dermatology and Venerology HELIOS Klinikum Krefeld, Germany


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Primary cutaneous T-cell lymphomas (PCLs) mycosis fungoides (MF) and Sézary syndrome (Ss) belong to the group of non-Hodgkin lymphomas (NHL), which are characterized by clonally proliferating CD4+ cells localized in the skin. Although there already exist many conventional skin-directed and systemic cytotoxic treatment options, in long-term only a transient remission without curative results will be reached in most cases. The aim of this article was to present actual assumed treatment modalities, as well as new therapeutic strategies which passed already through clinical trials showing promising results in the treatment of PCLs.

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