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Giornale Italiano di Dermatologia e Venereologia 2008 October;143(5):339-46

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Diffuse skin spread of HIV-associated visceral leishmaniasis: cumbersome diagnostic and therapeutic issues

Manfredi R. 1, Passarini B. 2, D’Antuono A. 2, Misciali C. 2, Marinacci G. 1, Calza L. 1

1 Division of Infectious Diseases Department of Internal Medicine, Aging and Nephrologic Diseases S. Orsola-Malpighi Hospital, Bologna, Italy 2 Division of Dermatology, “Alma Mater Studiorum” University of Bologna S. Orsola-Malpighi Hospital, Bologna, Italy


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An infrequent and atypical case report of HIV-associated visceral leishmaniasis complicated by a diffuse, aspecific maculo-papular cutaneous involvement was characterized by a prolonged course, and a lack of response to repeated attack/maintenance cycles performed with liposomal amphotericin B, despite a satisfactory immune response maintained thanks to a concurrent, potent combination antiretroviral treatment. Only a very prolonged administration of the older i.v. pentamidine isethionate together with oral paromomycin led to a slow, but complete cure of both visceral leishmaniasis and its related skin dissemination, in absence of adverse events and long-term disease relapses.

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