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Giornale Italiano di Dermatologia e Venereologia 2007 October;142(5):513-8

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

Psoriasis comorbidities reflect distinct mechanisms of disease

Christophers E.

Department of Dermatology Schleswig-Holstein University Clinics, Kiel, Germany


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Epidemiologicial studies recently have shown that psoriasis patients may suffer from associated disorders more frequently than expected. Such comorbidities include psoriatic arthritis, psoriatic pustular diseases, Crohn’s disease, and signs of metabolic syndrome which lead to atherosclerosis with coronary heart disease. Although the disorders represent separate entities they appear to follow overlapping pathogenetic pathways.
Duration and severity play a major role in developing psoriatic arthritis and metabolic dysfunction. Both comorbidities become clinically manifest years after the onset of psoriasis and are more often noted in severe disease. Persistent low grade inflammation with secretion of proinflammatory cytokine e.g. TNF-α favours the development of insulin resistance and metabolic syndrome. In addition biochemical and immunological observations point toward an inflammatory immune mechanism which uses tools of the innate defense armentarium.

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