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Giornale Italiano di Dermatologia e Venereologia 2007 October;142(5):489-501

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

The genetics of psoriasis susceptibility

Sánchez F.

Unit of Dermatology and Venereology Department of Medicine Karolinska Institute Stockholm, Sweden


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Psoriasis is a maladaptive dynamic response of human complex biological systems to environmental challenges. It manifests by altered keratinocyte proliferation and differentiation and by inflammation. Psoriasis cannot be defined by singular errors as in the case of mendelian diseases. The psoriasis system can be represented as having different layers of tightly regulated information (immunological, endocrine, metabolic, etc.), or as a robust adaptive network in which a minimal set of elements is prone to error. Because of our great capacity to collect genotypic and expression data, we are progressively acquiring a large inventory of psoriasis-associated factors, however, we need efficient methods to understand their functional role. We also need to pay more attention to studies aiming at discovering or understanding psoriasis triggers. Psoriasis research is yet to discover higher order interactions between genetic and environmental factors that will produce a more accurate, explanation-based definition of the disease. Systems biology may be the key to reach this goal.

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