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REVIEWS  CUTANEOUS MALIGNANCY UPDATE: MELANOMA IN 2007 

Giornale Italiano di Dermatologia e Venereologia 2007 April;142(2):71-82

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

The molecular mechanisms of melanoma tumorigenesis: an update

Gao L. 1, Zhao H. 2, Cornelius L. A. 1

1 Division of Dermatology Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA 2 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA


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Therapeutic resistance and proclivity for metastasis cast the dismal prognosis of cutaneous melanoma. Although recent discoveries in genetic, epidemiological and genomic studies bring some hope of improved understanding of melanoma pathogenesis, questions regarding underlying molecular heterogeneity of melanoma genesis remain. Mining these complexities will hopefully reveal clues essential to understanding disease pathogenesis, clinical behavior and response to therapy. Current advances in high-resolution genome-wide technologies, as well as gene-specific mutational analysis, in conjunction with genetic and phenotypic analyses, improved animal models, may ultimately help to better define the seminal molecular events contributing to disease pathogenesis and ultimately identify more effective therapeutic targets.

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