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Giornale Italiano di Dermatologia e Venereologia 2004 December;139(6):561-7

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: English, Italian

Follicular mycosis fungoides. a clinicopathological, and immunohistochemical study of two cases

Bongiorno M. R., Pistone G., Aricò M.

Department of Dermatology University of Palermo, Palermo, Italy


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The authors describe the clinical, histopathological and immunohistochemical features of 2 patients with strict follicular mycosis fungoides. The histopathological lesions seen in these patients are characterized by the aggregation of lymphocytes CD45Ro, CD3 and CD4 positive around and within hair follicular epithelium in absence of epidermotropism without spongiosis and mucinosis and an increased expression of ICAM-1 and HLA-DR in follicular keratinocytes. The factors that regulate the differential infiltration of tumour lymphocytes in follicular epithelium may be linked with over expression of ICAM-1 and HLA-DR in follicular epithelium. The local epithelial or follicular regulation of chimokines, their receptors and intercellular adhesion molecular-1 production, may explain the variability in localization patterns of mycosis fungoides. The follicular mycosis fungoides is an unusual variant of the exceedingly broad spectrum of mycosis fungoides.

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