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Giornale Italiano di Dermatologia e Venereologia 2004 June;139(3):207-30

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: English

The therapy of psoriasis based on innate and adaptive immune mechanisms of disease pathogenesis

Wang F. 1, Lew W. 2, Krueger J. G. 1

1 Laboratory for Investigative Dermatology Rockefeller University, New York, NY, USA 2 Department of Dermatology Yonsei University College of Medicine, Seoul, Korea


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Psoriasis vulgaris is the most prevalent T cell-mediated inflammatory condition in humans. The pathogenesis of psoriasis is linked to T cell-dependent inflammatory processes that lead to epidermal and vascular hyperproliferation. Critical steps in the immunologic activation of T-cells include: 1) contributions from adaptive immunity, including molecular interactions with dendritic cells, and 2) contributions from innate immunity, including the production of inflammatory cytokines by innate immune cells. Since both adaptive and innate immune mechanisms regulate leukocyte activation, blocking or modulating specific steps along these pathways represents potential therapeutic interventions for psoriasis.

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