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Giornale Italiano di Dermatologia e Venereologia 2004 February;139(1):31-46

Copyright © 2004 EDIZIONI MINERVA MEDICA

language: English, Italian

Drug-induced non-histaminergic angioedema

Zampino M. R., Corazza M., Virgili A.

Section of Dermatology Department of Clinical and Experimental Medicine University of Ferrara, Ferrara, Italy


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Angioedema (AE) is caused by various stimulating agents that lead to the release of chemical mediators capable of increasing vascular permeability at cutaneous and/or mucosal level. The pathogenetic mechanisms involved, whether of an immunological or non-immunological nature, lead to a wide range of clinical features in which histamine and the histamine-releasing cells can be considered the principal protagonists. The pathogenesis of non-immunological AE includes a C1-inhibitor deficiency and pharmacological mechanisms. This definition suggests that the causal agent probably acts with a biochemical mechanism rather than a histaminergic one. The purpose of this review is to offer a general survey of drug-associated AE, induced by mechanisms of a pharmacological-biochemical nature without activation of the immune system or release of histamine.

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