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Giornale Italiano di Dermatologia e Venereologia 2003 December;138(6):503-6

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: Italian

A case of generalized progressive morphea and lichen sclerosus

Schena D. 1, Giovannini A. 1, Germi L. 1, Colato C. 2, Barba A. 1, Chieregato G. 1

1 Sezione di Dermatologia e Venereologia, Dipartimento di Scienze Biomediche e Chirurgiche, Università degli Studi di Verona, Verona, 2 Unità Operativa di Anatomia e Istologia Patologica, Università degli Studi di Verona, Verona


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The case of a 73 years old female, affected by limited systemic scleroderma and lichen sclerosus of the vulva and of the extragenital area (back) is described. In 1997 the patient was diagnosed to be affected by morphea with ANA positive outcomes (>1:640 homogeneous) but without any systemic involvement. Since 1999, the patient referred the onset of erythematous-pruriginous lesions of the vulva and she was submitted, 2 years ago (in 2000), for a biopsy showing a papillomavirus infection. In June 2001, she was submitted to a further biopsy and the diagnosis was lichen sclerosus of the vulva. In October 2001, the patient was admitted at our Department and the following findings were observed: ANA=1:2560 homogeneous, diabetes mellitus type II, hypertension, urosepsis, and an oesophagus restriction, with a light wall rigidity, suggestive of systemic scleroderma. In March 2002, lichen sclerosus localized to the trunk was diagnosed. The importance of this report is due to the association between systemic scleroderma and lichen sclerosus and because, for several years, the etiopathogenesis of localized, systemic scleroderma and lichen sclerosus was the subject of discussions leading to consider lichen sclerosus, a different manifestation of the same disease or a well characterized disease occasionally associated with morphea.

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