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Giornale Italiano di Dermatologia e Venereologia 2002 December;137(6):377-82

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

p53 and melanogenesis

Kosmadaki M. G., Eller M. S., Gilchrest B. A.

Department of Dermatology Boston University School of Medicine, Boston, MA, USA


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This review discusses the role of p53 in melanogenesis. The production of melanin increases when human skin is exposed to UV irradiation and the resulting tan is photoprotective against further UV damage. This protective response of human skin to UV irradiation is stimulated by DNA damage and/or its repair. In addition to UV irradiation, small DNA oligonucleotides such as thymidine dinucleotides induce melanogenesis in a p53-dependent manner. p53 mediates, at least in part, the melanogenesis response and has a general role in rendering skin more resistant to subsequent UV irradiation.

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