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Giornale Italiano di Dermatologia e Venereologia 2002 August;137(4):271-3

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: Italian

SLE and pregnancy

Rampone A. 1, Rampone B. 2, Capuano I. 2, Tirabasso S. 2, Vozza G. 1, Vozza A. 1, Rampone N. 2

1 Unità Operativa di Clinica Dermatologica 2 Istituto di Clinica Ostetrica e Ginecologica Seconda Università degli Sudi di Napoli, Napoli


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Background. To evaluate the evolution of pregnancy in women suffering from Systemic Lupus Erythematosus (SLE).
Methods. Thirty pregnant women, with a clinical diagnosis of SLE in phase of remission, were examined between January 1998 and December 1999 at the Institute of Obstetrics and Gynecology of the Second University of Naples (SUN) in collaboration with the Institute of Dermosyphilopathy of the SUN. Mean patient’s age was 31.5 years (range 28-35). All the women examined were multiparous and were followed from the beginning of pregnancy up to delivery. The treatment of the illness in pregnancy was carried out by parenteral administration of glucocorticoids (betamethasone 1.5 mg/day for 10 days every month) in the all the cases.
Results. Such therapy did not influence the evolution of the pregnancy, the duration of labour, delivery and post-labour. In 90% of the cases the patients spontaneously gave birth during the 37th and 40th week.
Conclusions. The effects of SLE on pregnancy are therefore negative on its evolution since this illness causes a necrotizing vasculitis of the placental vessels, responsible for the functional insufficiency of this organ. In women suffering from SLE, in phase of remission and without serious lesions on the single organs or apparatuses, the pregnancy can evolve up to term with remarkable benefit from the administration of glucocorticoids that are well tolerated both by the mother and fetus.

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