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Giornale Italiano di Dermatologia e Venereologia 2001 December;136(6):453-5

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: English

Primary neuroendocrine (Merkel cell) carcinoma of the eyelid in a young woman. Report of a case

Miracco F., Miracco C. *, Schürfeld K. *, D’Aniello C. **, Grimaldi L. **, Pirtoli L. ***

From the Dipartimento di Scienze Oftalmologiche * Institute of Pathological Anatomy and Istology ** Unit of Plastic Surgery *** Institute of Radiotherapy University of the Study, Siena


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Primary neuroendocrine (Merkel cell) carcinoma (MCC) of the skin is an infrequent tumor which usually affects elderly patients. The histological and immunohistochemical features of a MCC occurred in a healthy 31-year-old woman are described. Sun exposure, immunosuppression, and chronic arsenicism are known to play a role in the genesis of MCC. Neither sun damage, nor arsenical exposure or immunosuppression were demonstrable in our case. Tumor cells strongly expressed p53, myc-2 and Bcl-2 proteins. The hypothesis that tumor growth may have been promoted by a deregulation of p-53, myc-2 and bcl-2 genes, is suggested.

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