Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2001 December;136(6) > Giornale Italiano di Dermatologia e Venereologia 2001 December;136(6):435-44

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints

 

REVIEWS   

Giornale Italiano di Dermatologia e Venereologia 2001 December;136(6):435-44

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: Italian

Matrix metalloproteinases and their interaction with adhesion molecules in human melanoma

Hofmann U. B., Westphal J. R., Van Muijen G. N. P., Bröcker E. B.

From the Department of Dermatology Julius-Maximilians University Würzburg, Germany * Department of Pathology University Medical Center St. Radboud Nijmegen, The Netherlands


PDF


Degradation of extracellular matrix (ECM) and adhesion of tumor cells to and detachment from other tumor cells and from the ECM are key steps in tumor invasion and metastasis. These processes all depend on coordinated expression of proteolytic enzymes and adhesion molecules. Various studies have analyzed the crucial role of matrix metalloproteinases (MMPs), their specific tissue inhibitors (TIMPs), and molecules that regulate their expression and/or activation in melanocytic tumor progression. Recent results have indicated that adhesion molecules such as integrin avb3 and CD44 are involved in positioning activated MMP molecules on the cell surface of invasive tumor cells. This review evaluates the role of MMPs and TIMPs, and the interactions between individual MMPs and cell adhesion molecules in human melanoma.

top of page