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Giornale Italiano di Dermatologia e Venereologia 2001 October;136(5):329-33

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: English

Radiotherapy of residual (incompletely excised) basal and squamous-cell carcinomas of the skin. Experien-ce in 87 cases with no evidence of clinical disease

Caccialanza M., Piccinno R., Bottelli S., Franchi C.

From the Servizio di Fotoradioterapia, Istituto di Scienze Dermatologiche dell’Università, Ospedale Maggiore IRCCS, Milano


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Background. Incompletely excised basal and squamous cell carcinomas of the skin (with histopathological ascertainment) with no evidence of clinical disease represent a yet unsolved therapeutic problem. Aim of this study was to evaluate whether radiotherapy was or not a safe and effective treatment in destroying the residual neoplastic cells and to prevent and/or reduce the onset of clinically evident relapses.
Methods. Therefore, a retrospective study was performed on 87 patients (77 with basal cell carcinoma and 10 with squamous cell carcinoma), that underwent orthovoltage radiotherapy in the period 1982-1999. The total doses administered ranged from 50 to 60 Gy. The mean follow-up was 46.37 months, planned according to a schedule of a first control 1 month after the end of radiotherapy, then a control every sixth month for 5 years, and a control once in a year. The cure-rate was evaluated according to the life-table method.
Results. The five-year cure-rate (after the end of radiotherapy) was 90.4%. Five recurrences have been observed in basal cell carcinomas, 2 centrally and 3 marginally respect to the irradiation field. The cosmetic results were evaluated as good or acceptable in 81% of cases. So far no complications nor sequelae to the treatment have been observed.
Conclusions. Radiotherapy has resulted as a safe and effective treatment with a low cost in the management of this kind of skin neoplasms.

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