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Giornale Italiano di Dermatologia e Venereologia 2001 June;136(3):187-94


language: Italian

Recovery of skin elasticity and turgor by intradermal injection of hyaluronic acid (Ial-System®) by the cross-linked technique

Di Pietro A., Di Sante G.

Ospedale di Inzago (Milano) Servizio di Dermatologia *FIDIA SpA - Abano Terme (Padova) Divisione Riparazione Tissutale


Background. Ageing of the facial skin is associated with slower cell turnover and a decrease in elastic tissue and hyaluronic acid.
The aim of the study was to assess whether intradermal injection by the cross-linked technique of a product based on natural hyaluronic acid (Ial-System™) was able to restore elasticity and turgor to the skin. Moreover, the degree of correction achieved and the safety of the product were also assessed.
Methods. Twenty adults with flaccid facial skin received 2 treatments (baseline, T15) with natural hyaluronic acid. Skin elasticity and turgor were assessed objectively with an Elastometer EM 25 at baseline (T0), before the second treatment (T15) and again 30 (T45) and 90 (T105) days later. The degree of correction was assessed clinically by a physician. The degree of satisfaction with the treatment was reported in terms of the physician’s and patient’s judgement of its performance and safety.
Results. Mean elasticity values increased from 51.25% at baseline to 57.6% at T15, to 62.65% at T45 and remained at 60.75% at T105. Mean turgor values were 0.74 at baseline, 0.77 at T15, 0.78 at T45 and T105. The effect of the treatment, assessed as the differences between baseline and T15, T45 and T105 was statistically significant at all times. The degree of correction was altogether acceptable even at T105. No adverse events other than those normally expected following injection (erythema, pain, oedema, ecchymosis) were observed.
Conclusions. The results confirm that hyaluronic acid is a suitable biomaterial for skin rejuvenation. Its excellent tolerability ensures its safe use to the physician and patient.

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