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Giornale Italiano di Dermatologia e Venereologia 2001 February;136(1):59-62

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: Italian

Infantile myofibromatosis. Description of a clinical case of a solitary plantar lesion

Bandini P., Passarini B., Patrizi A., Varotti C., Pasquinelli G.

Università degli Studi - Bologna Dipartimento di Medicina Clinica e Sperimentale Sezione di Clinica Dermatologica (Direttore: Prof. C. Varotti) *Unità Operativa di Anatomia Patologica Sezione di Diagnostica Strutturale


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The authors describe a case of a 5 month-old girl who presented since three months a solitary painful nodule on the left planta pedis. This lesion measured 3 cm of diameter, had a firm consistency and appeared erythematous. Microscopic examination of a excisional biopsy revealed into the dermis a non-encapsulated cellular tumor composed of interlacing bundle of spindle-shaped cells. Prominent vascular channels lined by flat endothelial cells were seen in some foci. Several rounded cells were arranged around the blood vessels. Ultrastructural evidence and immunoreactivity for vimentin and actin with negative staining for desmin, indicated that the spindle cells were myofibroblasts. The infant was otherwise healthy and complete internal examinations (routine laboratory parameter, chest and whole skeleton x-ray, abdominal sonography), were normal. The authors include this case in the infantile myofibromatosis. Finally, the precise nature of myofibroblast cells which have been regarded as intermediate in character between fibroblasts and smooth muscle cells, is discussed.

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