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Giornale Italiano di Dermatologia e Venereologia 2000 December;135(6):707-10

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

Atypical fibroxanthoma, clinical and histopathological observation

Bongiorno M. R., Pistone G., Aricò M.

Istituto di Clinica Dermosifilopatica - Palermo


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Atypical fibroxanthoma is a solitary, cutaneous, fibrohistiocytic neoplasm arising on actinically damaged skin of elderly persons. The case of an elderly patient with an atypical fibroxanthoma on the forehead presenting as an erythematous subepidermal nodule, indurated and non fixed to deeper structures is described. Histopathologically it is characterized by dermal nodule composed of bizarre cells arranged in a haphazard to fascicular pattern. The cells appear spindle or rounded. Some cells are polygonal, pleomorphic with atypical mitotic figures and with foamy and ample cytoplasm. Immuno-histochemistry revealed that neoplastic cells are cytokeratin and S-100 protein negative. The atypical fibroxantoma should always be considered as a low- grade malignant fibrous histiocytoma.

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