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Giornale Italiano di Dermatologia e Venereologia 2000 October;135(5):643-5


language: Italian

Comparative clinical study in the treatment of acne

Rigoni C., Spinelli G., Demichelis P., Toffolo P., Innocenti M., Cantù A. M.

Università degli Studi - Milano Istituto di Scienze Dermatologiche IRCCS «Ospedale Maggiore» - Milano


Background. A study was carried out in order to evaluate the efficacy of treatment for acne with a topic preparation containing 10% glycolic acid and 2% zinc pidolate (EFFALPHA®) and to compare it with 3% erythromycin gel and a combination of the two products, used on alternate days.
Methods. A total of 90 patients were treated, aged between 15 and 30 years (average 22.5). The group of 30 patients treated with glycolic acid and zinc pidolate was made up of 7 male and 23 female subjects, the group treated with only erythromycin of 8 males ad 22 females and the group treated with an association of the two products consisted of 12 male and 18 female subjects. Clinical findings were taken at base time and after 30 and 60 days of treatment. The gravity of the acne condition was evaluated using a numerical scale of 1 to 3, where; 1 = blackheads only; 2 = blackheads + papules; 3 = blackheads + papules + pustules. At the end of the observation period, the clinical evaluation of the efficacy and tolerability of the medical preparation; the degree to which the product was accepted by the patient and the onset and quantification of any side effects were recorded.
Results. The data reveal that all the forms of treatment adopted in the study were well tolerated and accepted by the patients and no adverse reactions were observed in any subjects.
Conclusions. The best clinical results were obtained by the group using an association of glycolic acid-zinc pidolate and erythromycin on alternate days.

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