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Giornale Italiano di Dermatologia e Venereologia 2000 October;135(5):597-605

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

Rare cutaneous tumors in transplant recipients. Personal clinical experience and literature review

Picciotto F., Basolo B. *, Massara C. *, Aloi F. **, Segoloni G. P. ***, Quarello F. *

IRCC Ordine Mauriziano - Candiolo (Torino) U.O. Oncologia Dermochirurgica Ospedale Giovanni Bosco - Torino * Divisione di Nefrologia e Dialisi ASL IV Università degli Studi di Torino ** II Clinica Dermatologica (Direttore: Prof. M. Pippione) *** Centro Trapianti Renali Divisione di Nefrologia e Dialisi (Direttore: Prof. G. Piccoli)


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In spite of therapeutic immunosuppression carried out to avoid organ rejection, increased risks of neoplasias are described in transplant recipients. Cutaneous squamous carcinomas (40% of patients affected after 20 years of transplantation) and Kaposi sarcomas (400-500 fold higher incidence compared to similar ethnic normal population) are the most common skin lesions. Besides these well known lesions, rare cutaneous and soft tissue tumors are observed in these patients: dermatofibrosarcoma protuberans, atypical fibraxantomas, Merkel cell carcinomas, hemangiosarcomas. The incidence of some of these lesions seems to be increased with respect to normal population, and probably immunosuppression is responsible for a high biological aggressivity. The authors discuss their clinical experience, review the literature on the pathogenetic aspects and point out some strategies of prevention and dermatological management.

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