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Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):643-6

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Multicentric Paget’s disease. A case report

Nicolella D. 1, Iandoli R. 2, Belli M. A. 2

1 A. O. Moscati - Avellino, Unità Operativa di Oncologia; 2 A. O. Moscati - Avellino, Unità Operativa di Dermatologia


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Paget’s Disease is an epidermal adenocarcinoma presenting as exudative eczematous lesions joining in red plaques, while the histology emphasizes the presence of great clear cells called “Paget’s cells”. A mammary(MPD) and extramammary (EPD) disease are distinguished: the last may involve genital (vulva, scrotum),groin-perineal or axillar areas, and sometimes is associated with an adjacent apocrine or eccrine gland carcinoma, or a concomitant gastrointestinal or genitourinary cancer(rectum, cervix, urethra). A case of unusual multicentric (mammary and extramammary) Paget’s disease, associated with vulvar and breast carcinomas, is reported. The clinical features and relationships with to pathogenetic theories are discussed.

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