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Giornale Italiano di Dermatologia e Venereologia 1999 December;134(6):599-601

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Ionizing radiation-induced pemphigus and delayed diagnosis

Hendrickx I., Guizzardi M., Mancini L. L., Monti M.

Università degli Studi - Milano, Unità Operativa di Dermatologia, Istituto Clinico Humanitas


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Ionizing radiation-induced pemphigus is a rare reported clinical entity, arising after a radiation therapy that usually follows surgical treatment for malignancy. A case of ionizing radiation-induced pemphigus arised after X-ray therapy for mammary carcinoma is reported. After two weeks of X-ray delivery, erythema and erosions appeared on the radiated area. These lesions were interpreted as an inflammatory result of radiation and cured. After eighteen months, typical pemphigus bullous eruptions developed all over the body and oral mucosa. The importance of considering ionizing radiation-induced pemphigus among the attending side effects of radiotherapy is underlined and it is suggested to submit to dermatological attention every case of uncertain skin reaction.

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