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Giornale Italiano di Dermatologia e Venereologia 1999 August;134(4):383-90

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Clinical, histological and immunohistochemical evaluation of the effects of topical calcipotriol in seborrheic keratoses

Brunetti R. 1, Castagna M. 2, Boccardi B. 2, Cervadoro G. 1, Pingitore R. 2

1 Università degli Studi - Pisa, Scuola di Specializzazione in Dermatologia e Venereologia; 2 Laboratorio di Anatomia Patologica del Dipartimento di Chirurgia


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Background. The aim of the study is a clinical, histological and immunohistochemical evaluation of the effect of topical calcipotriol in seborrheic keratoses.
Methods. Seventeen patients with seborreich keratoses of the trunk applied calcipotriol ointment on one lesion for a period of 12 weeks. At the end of the treatment, for each patient, both the treated lesion and untreated one were resected. The histological specimens were investigated with monoclonal antibody PC10 (for PCNA antigen), AE1 (for acid cytokeratins) and AE3 (for basic cytokeratins). At clinical examination the treated lesions were reduced with regard to thickness and diameter.
Results. The measurement with the microscope confirmed a reduction of thickness (mean 0.43 mm) in comparison with the untreated lesions (mean 1.05 mm). In the untreated lesions the percentage of PCNA positive cells (mean 17.8) was higher in comparison with the treated lesions (mean 7.18 %). The majority of the untreated lesions showed positivity superior to 10% while only few treated cases were above this value. In 1/3 of the untreated lesions, AE1 did not mark the basal layer while in the treated lesions this antibody marked the basal layer. AE3 marked all the layers of the lesions both in untreated and in treated lesions.
Conclusions. The topical calcipotriol reduced the clinical expression of seborrheic keratoses but did not determine the total regression. The most significant effect concerns the lesions’ thickness, measured from the basal layer to the granulous one. As well as psoriasis, also in seborrheic keratoses, calcipotriol interferes with the proliferation and differentiation of the cells. It is possible that calcipotriol reduces the staminal compartment.

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