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Giornale Italiano di Dermatologia e Venereologia 1999 April;134(2):157-62

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Comparative study of the calcipotriol-microemulsions association in patients with psoriasis

Chieregato G., Schena D., Rosina P., Colombari R.

Università degli Studi - Verona, Istituto di Dermatologia e Venereologia


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Background. Microemulsions have been demonstrated to be useful to carry substances with stimulant and therapeutic effects into the deeper layers of skin. To evaluate this hypothesis, the effectiveness of Capsoft products (regulator spray + balancing cream) applied alone, in association or before calcipotriol in patients with medium-severe degree of psoriasis has been studied. To obtain the more homogeneous subjects for the investigation, four male patients, mean age 55, with plaques and nummular psoriasis (3 plaques and 1 nummular) have been selected from a large outpatients group.
Methods. Clinical features were: lesions’ symmetrical disposition, uniform severity of disease and at least 10 years of disease duration. All patients were free from topical and/or systemic treatment since at least 1 month. After having obtained informed consent, calcipotriol-microemulsions together and micro-emulsions followed after 15 days by calcipotriol, were applied in different but symmetrical skin areas. As control single component applications were performed in the same subjects. Clinical and histological changes of all the treated areas were evaluated at different times (before and after 2 and 4 weeks from treatment).
Results. The microemulsions as single therapy demonstrate to be a useful coadjuvant treatment in patients with medium-severe psoriasis. The application of microemulsions in association with calcipotriol has produced a more rapid and more evident clinical and histological lesions regression even in patients with severe psoriasis.
Conclusions. The application of microemulsions-calcipotriol at the same time produces better clinical and histological effects than the other treatment schemes used.

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