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Giornale Italiano di Dermatologia e Venereologia 1999 February;134(1):41-4

Copyright © 1999 EDIZIONI MINERVA MEDICA

language: Italian

Seborrheic pemphigoid. Description of a clinical case

Pranteda G., Bottoni U., Innocenzi D., De Simone P., Silipo V., Calvieri S.

Università degli Studi di Roma «La Sapienza» - Roma, Clinica Dermatologica


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Bullous Pemphigoid (BP) is a chronic autoimmune disease, characterized by production of autoantibodies against a specific antigen (BP antigen), localyzed on the basal membrane. Several clinical variants of bullous pemphigoid are known, among them: pemphigoid vegetans, pemphigoid sine materia, papular, and nodular pemphigoid, anular centrifugum-like erythema pemphigoid, childhood pemphigoid, localized pemphigoid. In 1969 Schnyder described a clinical variant of BP localized to seborrheic regions, defining thus a new nosologic entity with the name of Seborrheic Pemphigoid (SP). A case of SP in a 59-year-old man, characterized by blistering on nose, temporal and back erythematous skin, since one year is described. The lesions showed a chronical-recurrent trend with worsening after sun exposure. The clinical data together with the histological and immunofluorescence tests made it possible to diagnose SP The etiology of BP is controversial. In the localized forms it is presumed that trauma, UV and ionizing radiations could play a fundamental role in determining the disease in genetically predisposed individuals or in subjects affected by a subclinical bullous disease. The rarity of these reports in the literature is underlined and, particularly the close connection between fotoexposure and clinical features of the disease is stressed.

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