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Giornale Italiano di Dermatologia e Venereologia 1998 October;133(5):373-80

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: English

Management of some inflammatory dermatoses with a cosmetic preparation containing antioxidant/antiinflammatory agents

Vena G. A., Cassano N., Mastrolonardo M., Loconsole F., Coviello C., Arpaia N.

From the Università degli Studi di Bari - Bari, Istituto di Clinica Dermatologica


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In the ­last 5 ­years we have verified the effi­ca­cy of a top­i­cal prep­ar­a­tion (Lichtena® AI ­cream, UCB Pharma Italy) in var­i­ous inflam­ma­to­ry ­skin dis­eas­es. Lichtena® AI ­cream con­tains 0.7% ­fural-glu­ci­tol, an anti­ox­i­dant ­agent, ­along ­with oth­er com­pounds pro­vid­ed ­with pos­sible antiin­flam­ma­to­ry and anti­ox­i­dant prop­er­ties.
In par­tic­u­lar, the ­effects of the ­cream ­were eval­u­at­ed in ­patients ­with the fol­low­ing ­skin dis­or­ders: irri­tant and aller­gic con­tact der­ma­titis (42 ­patients), atop­ic der­ma­titis (22 ­patients), seb­or­rhe­ic der­ma­titis of child­hood and adult­hood (18 and 106 cas­es, respec­tive­ly), cuta­ne­ous ­lupus ery­them­a­to­sus (8 cas­es), pho­to­con­tact der­ma­titis (2 cas­es), and actin­ic retic­u­loid (2 cas­es). All the ­patients ­were request­ed to ­apply ­twice dai­ly a ­small ­amount of the ­cream to the lesion­al ­skin for a ­mean peri­od of 8 ­weeks. The treat­ment ­gave ­good to excel­lent ­results in a rel­e­vant ­rate of cas­es in ­terms of ­both ­patients’ ­self-per­ceived ­response and objec­tive improve­ment of cuta­ne­ous ­signs of the dis­ease.
The ­results ­obtained in our and ­some ­others’ expe­ri­enc­es indi­cate the fea­sibil­ity of the ­cream as an alter­na­tive, ster­oid-spar­ing ther­a­peu­ti­cal ­tool. The ­exact mech­a­nism of ­action of the prep­ar­a­tion is not yet under­stood: it is like­ly ­that ­some ­active ingre­dients, pos­sibly inter­act­ing ­each oth­er ­with syn­er­gis­tic and pot­en­tiat­ing ­effects, medi­ate the antiin­flam­ma­to­ry ­action, and ­that, in ­this con­text, anti­ox­i­dants ­play a rel­e­vant ­role.

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