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Giornale Italiano di Dermatologia e Venereologia 1998 August;133(4):299-303

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: Italian

Treatment of intertrigo with a chloroxylenol and eosine anti-septic solution. A controlled double-blind study versus eosine solution

Galbiati G., Scarabelli G.

Azienda Ospedaliera San Gerardo - Monza (Milano), Divisione Dermatologica


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Background. The aim of the present controlled double-blind clinical study in parallel groups, was to test if the combination of 0.3% chloroxylenol and 2% eosine in a water-glycol solution exhibits therapeutic advantages versus a 2% water solution of eosine in therapy of dermatologic pathologic states of the large folds.
Methods. To this purpose, 43 adult patients of both sexes with mono- or multifocal intertrigo, were enrolled. They signed their informed consent. Both solutions were applied with a brush onto the injured area twice-a-day, for a period ranging from 1 to 3 weeks depending on the evolution of the dermatologic disease. At the clinical controls, baseline and at the end of each week of therapy till the cure, the presence and size of subjective (itching, burning, tickling, pain) and objective symptoms (motor dysfunction, basal erythema, edema, vesiculation, exudation, maceration, evil-smelling secretion, flaking and pustulation), which characterized the dermatosis in question, were assessed.
Results. The antiseptic combination was found to be clinically more active than the water solution of eosine, since it induced a faster and more significant remission (p<0.01) of subjective and objective symptoms, with a complete resolution of dermatosis. Moreover, the antiseptic combination was perfectly well tolerated, since it never induced local irritative phenomena or sensitization. This may be probably correlated to the poor allergizing potency of chloroxylenol — at the concentration employed — and to the high degree of purity of eosine (≥97%) employed in the present study.
Conclusions. In conclusion, we may critically state that this combination could be usefully employed in irritative, allergic and microbial pathologic states of body folds.

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