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Giornale Italiano di Dermatologia e Venereologia 1998 August;133(4):251-5

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: Italian

Experimental skin infections in rats infected by Pseudo-monas aeruginosa and undergoing hyperbaric oxygen therapy

Marmo M.

II Università degli Studi - Napoli, Istituto di Anestesia, Analgesia, Rianimazione e Terapia Intensiva, Servizio di Terapia Iperbarica


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Background and methods. About 80% of nosocomial infections are caused by aerobic bacteria. The Pseudomonas aeruginosa is a Gram-negative bacterium pertaining to the Pseudomonadaceae family. P. aeruginosa is responsible for 6-22% of all hospital infections.
The aim of this paper is to evaluate the efficacy of both hyperbaric oxygen-therapy (HBO) 2 Atm×35 min/day alone for 8 day and when associated to the chemoantibiotic therapy (amikacine, 15 mg/kg/day for 8 days intraperitoneal), in rats infected through subcutaneous intake by P. aeruginosa, 5×106 (CFU)/100 µl (Sprague-Dawley).
Results. The results show that in rats infected by P. aeruginosa, HBO induces a significant reduction in mortality and morbility with bacteria eradication in blood culture findings and skin biopsies.
Conclusions. These effects were increased by the use of amikacine which is an antibiotic used for the treatment of Gram-negative bacteria.

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