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Giornale Italiano di Dermatologia e Venereologia 1998 April;133(2):145-53


language: Italian

Aqueous extract of “triticum vulgare”. Clinical and histological evaluation in cutaneous tissue repair process

Mastroianni A., Celleno L., Borgia M. G., Cerimele D.

Università Cattolica del Sacro Cuore - Roma, Istituto di Clinica Dermatologica (Direttore: Prof. D. Cerimele)


The healing of an adult skin wound is a complex process involving dermal repair and epidermal regeneration. The failure of chronic wounds to heal remains an important medical problem. Recent studies have suggested an important role for aqueous extract of “triticum vulgare” in promoting wound healing. “Triticum vulgare” seems to have an important role in cellular proliferation and wound healing and to be capable of stimulating mitosis of epidermal and dermal cells. The authors evaluated, in cutaneous lesions produced by vascular alterations (leg ulcers), characterized by a slow resolution, the efficacy of aqueous extract of “triticum vulgare” in promoting cutaneous tissue repairs. The study has been carried out by confronting, on lesions affecting the same subject, the healing time obtained by using “triticum vulgare” or other dermatological topical therapy (topical antibiotics and disinfectants). The subjects had their wounds dressed with extract of “triticum vulgare” daily administered for a period of thirty days. Skin biopsy was obtained from the leg ulcers, after voluntary consent, on days 0, 7, 14 and 30. Hematoxylin and eosin stained sections were analyzed using optical microscope. Ultra-thin sections were viewed under the transmission electron microscope. Photographs were taken with optical and electron microscope to study cell proliferation during wound healing. Aqueous extract of “triticum vulgare” showed its efficacy in promoting tissue-repair process. It was able to support the wound repair process about epidermal regeneration. This extract, helped the cutaneous wound healing with its mitogenic effect on fibroblast and endothelial cells into the derma and effecting the epidermal cells proliferation in damaged epidermal area.

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