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Chirurgia 2022 October;35(5):255-61

DOI: 10.23736/S0394-9508.20.05217-1


language: English

Role of autologous platelet rich plasma in hypospadias repair

Ahmed S. DARWISH 1 , Osama A. ELNAGGAR 2, Amr A. ZAKI 2, Noha M. KAMEL 1, Mohamed M. DAHAB 2, Karam EL-SAYEM 1

1 Faculty of Medicine, Suez Canal University, Ismailia, Egypt; 2 Department of Pediatric Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt

BACKGROUND: The prevalence of hypospadias is estimated to be 11.3 of 10000 to affect less than 0.1% of newborns worldwide. Several have been developing to improve the outcomes. So, this study aimed to evaluate effectiveness of autologous PRP in healing promotion and role of autologous PRP in in-situ regenerative therapy techniques in surgery.
METHODS: This randomized prospective controlled study; we included 30 children who aged between 6 months and 12 years. For two years, we recruited patients from Pediatric Surgery department at Ain Shams University Hospital, and Suez Canal University Hospital. In this study we divided the study population into two groups as following. Group A: we used buccal mucosa or foreskin graft as first stage with autologous PRP gel and Group B: we used buccal mucosa or foreskin graft as first stage without autologous PRP gel.
RESULTS: The mean operation time was the longest in group A, with a mean of 192 minutes. There is a statistically insignificant relationship between the type of hypospadias repair and the operation time. Procedures with autologous PRP tend to have more operation time than those without. For instance graft infection happened only in group B. Unlike group B, all patients in group A experienced graft taking, while 2 of group A did not. Of notice, edema occurred with the all 4 groups. All patients at group A and B had edema. The total number of reported complications among group A was quite similar; however less than that reported among group B. None of these complications was statistically significant different between both groups. Regarding VSS score, it was significantly higher among group B.
CONCLUSIONS: PRP is considered as an advisable method for local wound management; PRP can improve wound healing and reduce risk of infection.

KEY WORDS: Hypospadias; Surgery; Platelet-rich plasma

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