CASE REPORT   

Chirurgia 2021 October;34(5):222-6

DOI: 10.23736/S0394-9508.20.05227-4

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Breast implant-associated anaplastic large cell lymphoma: case report and literature review

Rebecca J. FISHER ¹ ✉, Kishan P. PAREKH ¹, Rebecca HARSTEN ², Philip IDAEWOR ¹, Abdalla SAAD ABDALLA AL-ZAWI ¹, Wayne CHICKEN ¹

¹ Department of Surgery, Basildon and Thurrock University Hospital, Basildon, UK; ² Department of Surgery, Royal London Hospital, London, UK

The number of reported cases of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is increasing along with attention and discussion amongst physicians. After first being described in 1997, the World Health Organization in 2016 classified BIA-ALCL as a mature T cell neoplasm. This increasing acknowledgment and awareness will help in guiding management towards appropriate diagnosis and effective treatment. BIA-ALCL is originally a T-cell lymphoma, where the malignant T-cells have a large pleomorphic and anaplastic morphology. The immuno-histochemistry expresses immuno-reactivity to CD30. It is an anaplastic lymphoma kinase (ALK) surface receptor negative anaplastic large cell lymphoma. We present an additional case of BIA-ALCL, the presentation and management; and provide an overview of the literature related to this condition.

KEY WORDS: Lymphoma, large-cell, anaplastic; T-lymphocytes, cytotoxic; Breast implants