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Chirurgia 2021 April;34(2):66-71

DOI: 10.23736/S0394-9508.20.05119-0


language: English

Role of autologous platelet rich plasma in management of chronic wounds

Walid M. GAMAL 1 , Mohammed A. OMAR 2, Aly H. RASHWAN 1, Abdrheem F. MOHAMED 1

1 Department of Vascular and Endovascular Surgery, Qena University Hospitals, South Valley University, Qena, Egypt; 2 Department of General Surgery, Qena University Hospitals, South Valley University, Qena, Egypt

BACKGROUND: Prevalence of chronic non healing wounds in the world ranges from 1.9 to 13.1%. It is expected to increase as the population is getting old. It is estimated that almost 10% of the population would develop a chronic wound with a wound related mortality rate of 2.5%. The aim of this study was to determine the efficacy of platelet rich plasma (PRP) in chronic wound healing.
METHODS: Forty patients of either sex, 28 patients (70%) were males and 12(30%) were females with a mean age of 45.7 years, presented with chronic wounds of more than 6 weeks duration either diabetic, venous or traumatic wounds in nature were included in our study. Patients with ABI<0.9, infected wounds and uncontrolled diabetic patients were excluded. Under aseptic precautions, platelet rich plasma (PRP) was prepared. PRP was used by either local injection in the wound edges or as a soaked dressing “non absorbable dressing with paraffin gauze.”
RESULTS: In 40 patients, 34 wounds (85%) were due to diabetes, 5 wounds (12.5%) were venous ulcers and in only1 patient (2.5%) the wound was traumatic in nature. Pretreatment wound area was 4.5±5.8 and after the 6th session of injection it had become 1±2.1 which showed wound area reduction by 77.8% with highly significant difference as P value <0.001.
CONCLUSIONS: PRP promotes the healing of previously chronic non healing ulcers. PRP seems to have a beneficial effect on different wound etiologies.

KEY WORDS: Diabetic foot; Varicose ulcers; Platelet-rich plasma; Wounds and injuries

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