CASE REPORT   

Chirurgia 2020 June;33(3):174-9

DOI: 10.23736/S0394-9508.19.05003-4

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Laparoscopic treatment of mixed adenoneuroendocrine cancer of right colon: case report and review of literature

Giovanni MEROLA ¹ ✉, Umberto BRACALE ¹, Maurizio SODO ², Jacopo ANDREUCCETTI ³, Giusto PIGNATA ⁴

¹ Department of Gastroenterology, Endocrinology and Endoscopic Surgery, School of Medicine Federico II, Naples, Italy; ² Department of Public Health, School of Medicine Federico II, Naples, Italy; ³ Department of General and Mini-invasive Surgery of San Camillo Hospital, Trento, Italy; ⁴ Department of General Surgery II, Spedali Civili of Brescia, Brescia, Italy

Mixed adeno-neuroendocrine cancer (MANEC) term was introduced for the first time in WHO Classification of Gastrointestinal tumors in 2010. It represents a very rare neoplasm assessing about the 0.2% of all gastrointestinal cancer. The perioperative management is very challenging because of the poor knowledge of the biology of this cancer and the relative impossibility to make a diagnosis only by the biopsy during the colonoscopy. In this paper we present the case of a 83- year- old woman affected by right colon sited neoplasm with liver metastasis, which resulted to be a MANEC. The patient underwent to laparoscopic right colectomy and wedge resection of liver metastasis. The post-operative period was uneventful, and the patient was fit to be discharged at third post-operative day. A literature review about the etiology, diagnosis and treatment of right colon sited MANEC has been carried out and only eight papers about right sited MANEC have been found.

KEY WORDS: Colon, ascending; Laparoscopy; Neoplasms