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CASE REPORT   

Chirurgia 2018 October;31(5):215-8

DOI: 10.23736/S0394-9508.18.04773-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

A case of parathyroid cancer first revealed by a brown tumor of the mandible

Giulia LO BIANCO 1 , Fabio UGGERI 1, Marco CASATI 2, Chiara VILLA 3, Giovanni COLOMBO 4

1 Department of Surgery and Translational Medicine, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy; 2 Laboratory of Chemical-Clinical Analysis, San Gerardo Hospital, Monza, Italy; 3 Department of Otorhinolaringology, San Gerardo Hospital, Monza, Italy; 4 Department of General Surgery, San Gerardo Hospital, Monza, Italy


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Parathyroid cancer is a rare neoplasm accounting for 0.1% of all malignancies. There is no validated indication and little experience to guide us in the diagnosis and treatment of this condition that requires a high level of clinical suspicion. The present report concerns a case of parathyroid cancer that primarily manifested through the appearance of a brown tumor of the mandible, a circumstance that up to date has only been described exceptionally. This unusual presentation of an already uncommon medical condition in an otherwise healthy and asymptomatic woman lead to a delay in diagnosis and to futile investigations. We treated the patient performing radical en-bloc excision of the mass and of the homolateral thyroid lobe. In the absence of clear guidelines and having found no pathological nodes at surgical exploration we decided to refrain from performing a cervical lymphoadenectomy and to put the patient under strict follow-up. Further research, more information and the definition of common rules for management of parathyroid carcinoma are needed to help recognize and treat this rare neoplasm promptly and correctly.


KEY WORDS: Parathyroid neoplasms - Osteitis fibrosa cystica - Conservative treatment

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